I'm not griping about E10 fuel. It's here to stay. I build for it, cope with it, and accept it for what it is.
That being said, most of my issues come from the floats breaking down. I run giant filters, make sure I've got great gaskets, have run K&N filters, and everything one is supposed to do.
After a few years of E10 fuel, the floats start breaking down. New ones are not cheap, but worth every penny.