The problem with a big wheel in a Spyder is getting DOWN into the car and UP out of it. Combine that with a too-tall shifter and in/out becomes a real PIA. Just another one of those touchpoints Stan was talking about.
If you and the car FIT: seats/pedals/shifter/throttle response and wheel, nothing else much matters. If all those components work well also, you're ahead of the game. That's what I aim for when tweaking stuff. Top it off with the view of the gauges, over the dash, down the hood and to the road beckoning you to GO FASTER, you'll have a winner.