You probably won't notice much of a difference unless you're at full throttle and reading a wideband A/F gauge. Somewhere in the 1800-3000 rpm range, you might feel a little less oomph if it goes lean.
At part throttle you won't feel a difference.
Jet the idles and mains first, and make sure they're correct. Only then do you play with air correctors, emulsion tubes, and float height.
And make sure you're at 3 psi for IDFs, not over 3.5 MAX, that still holds true.