St. Louis is 2-1/2 hrs down the interstate highway, and Barnes- Jewish Hospital is a landmark nobody can miss. Barnes is a level 1 trauma center, so it's got really easy access to the highway, and we lived a mile from the interstate that ran directly to it. It's ridiculously easy to get to.
9-1/2 years ago, my eldest daughter was having a very, very complicated pregnancy (Twin to Twin Transfusion Syndrome), and they transferred her to Barnes when the local hospital was ready to be done with her.
Jeanie was with her in the hospital every day (and Alissa was in the hospital for almost the entire pregnancy), so she drove her down to STL, using the nav system as her guide. It took 6 hrs to get there. They were on the interstate for less than 30 minutes, then detoured onto progressively smaller and smaller roads until they were on county blacktops somewhere in rural Missouri. They eventually made it, but not before I was ready to send out the National Guard.
We haven't used it much in any vehicle since, even though we've got it. I use GoogleMaps all the time, and just link it to the infotainment system via CarPlay. I'd never willingly give money for a Nav system again, but it comes as part of the "grandkids watch Wreck It Ralph for the 1200th time" package.
I like paper maps as well.