When I had a 2000 F150 it had a problem with failing coil packs. It had 8 ignition coils, one on top of each spark plug and they were subjected to cylinder head heat all the time, so they failed, randomly.
Trying to get ahead of it just before we were scheduled to make our pilgrimage to South Carolina from Rhode Island, I bit the bullet and replaced ALL of them, to the tune of about $650. It started and ran like a top.
We got packed (we would fill the back of the truck with "stuff" from one house to the other) and took off. Just about the time we got to I-95 in Rhode Island, the engine started to skip constantly. Nothing affected the skip - it was there all the time. "Screw it!" I thought, and we kept going, expecting to fix it when we got there, 1,000 miles later.
When we arrived, I went to the Ford dealer and the service tech told me I had a bad coil pack. "Impossible!", I said. "They're all brand new!"
He told me that they get roughly 10% - 15% of their electronic parts that are DOA when they install them. They (we) just have to deal with it.