For me, I'd only do twin-plug with crankfire ignition and smart coils. Smart coils take care of triggering and dwell with built-in circuitry. This way, you only need one ignition controller.
Megajolt using EDIS is a great system, I've run it since 2008. But it uses dumb coilpacks. Dumb coils require an ignition driver for each coil, which requires 2 EDIS(Ford) boxes. Theoretically one crank trigger and one Megajolt should be able to operate two EDIS boxes. But if it was me, I'd use a system designed to accommodate smart coils for a twin-plug application.
With a 36-1 trigger wheel(35 teeth and 1 missing tooth for TDC location) it's accurate to 1/10 of a degree per revolution. That's a FAR cry from the +/- 5 degrees of a typical POS 009.
It's not very well known, but RETARDING advance by 1 degree per 250 rpms above 4800 really helps keep it cool to redline, especially under full load. SO this means that my max advance of 32 ends up at ~25 at redline of 6500. This is really only possible with a computer-controlled system. No way to do it with a distributor. Jake Raby told me this years ago, and I've been running this way with complete success since 2008.